Patient optimization, recruitment and retention, a key determinant of the success of a clinical trial, has always been a challenge. It is becoming more challenging with the increased complexity of clinical trial design, stringent eligibility criteria and the trend toward more targeted patient population. Considering importance of patient recruitment & retention in clinical trials to achieve the business objective but surprisingly, many companies do not dedicate any funds to this activity in the initial budgeting process. In fact, many companies do not plan for patient recruitment at all, believing that patient recruitment will happen some companies invest a lump sum to CROs, SMOs or sites and rely on them to recruit patients.